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Jessica Duncan, an obesity medicine physician and chief medical officer at the telehealth practice Ivim Health, who testified before the panel

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While some people report feeling more "clear-headed" or energized within a few days, the most significant benefits, such as changes in skin appearance or overall wellness, typically become visible after 4 to 8 weeks of consistent daily use

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For example, a long-term follow-up of 410 Thai women with melasma treated with dermabrasion evidenced a 95% sustained effect for 5 years and a low rate of adverse effects